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. 2019 Jun 3;38(14):e101082. doi: 10.15252/embj.2018101082

Figure 3. The centriolar satellite proteome is enriched in centrosome‐ and cilia‐related proteins.

Figure 3

  1. Venn diagram of total protein numbers from CS‐WT and known satellite components. Note that this and all subsequent analyses were performed on human orthologues of the chicken proteins from CS‐WT.
  2. Table depicts previously reported satellite components and their status in CS‐WT. Note that the current Ensembl/UNIPROT annotation fails to detect SPAG5.
  3. Gene Ontology (GO) enrichment analysis performed on CS‐WT. Selected terms with high significance are shown with the corresponding Benjamini–Hochberg adjusted P values.
  4. Venn diagram of total protein numbers from CS‐WT and the comprehensive proteomic dataset of centrosomes as reported in Jakobsen et al (2011).
  5. Schematics depict a selection of known and newly identified (bold) satellite candidates (from CS‐WT) and the centrosomal substructures and/or pathways they are implicated in. PLK4 is marked with an asterisk, as it was detected only in CS‐STIL. Several ciliopathy‐associated proteins are found in CS‐WT including newly identified candidates (bold). NEK2 is marked with two asterisks, as it was also shown to partially co‐localise with PCM1 by Hames et al (2005).