Table 7.

Covariance model and significance of predictors of global DNA methylation of patients undergoing pre-treatment for colorectal adenocarcinoma.

Global DNA Methylation	p
in tumor
Model (DFE diet + serum folate + tumor staging)	0.37
DFE diet 1	0.41
Tumor staging Serum folate	0.39 0.24
in blood
Model (DFE diet + serum folate + tumor staging)	0.01 *
DFE diet	0.15
Tumor staging Serum folate	0.03 * 0.02 *

DFE = dietary folate equivalent; ¹ DFE diet = natural folate + 1.7 × (synthetic folate in diet); * p < 0.05.