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. 2019 Jun 18;20(12):2979. doi: 10.3390/ijms20122979

Table 1.

Expression of P2 purinergic receptors in the cochlea before and after hearing onset (P15) in rodents. It includes only subtype and cell specific results. mRNA detection means PCR analysis and in situ hybridization, protein detection means Western-blot analysis and immunohistochemistry, while functional detection indicates pharmacological analysis in electrophysiological or Ca2+ imaging experiments. Results from guinea pigs are not separated by age as these animals have in utero hearing. These data are shown in the second part (P > 15) of the table. IHC: Inner hair cell; OHC: Outer hair cell; SGN: Spiral ganglion neuron; IBC: Inner boarder cells; IPhC: Inner phalangeal cell; PC: Pillar cell; DC: Deiters’ cell; HC: Hensen’s cell; OSC: Outer sulcus cell; SV: Stria vascularis; RM: Reissner’s membrane.

P2 Receptor Subtypes Presence in the Cochlea (P < 15)
Species Detected OHC IHC SGN IBC & IPhC PC DC HC OSC SV RM
P2X1 rat protein [61] [61]
P2X2 rat mRNA [47,52] [47,52] [47,52,56,57] [47] [47] [47,52] [47] [47] [47] [47]
mouse protein [42,49] [49] [49] [49]
function [46]
P2X3 rat mRNA [56,57]
protein [60]
mouse protein [65] [65] [65]
P2X4 rat mRNA [56,57]
P2X7 rat mRNA [56]
protein [62]
P2Y1 rat protein [66]
P2Y2 rat protein [66] [66] [66] [66] [66] [66]
function [67] [67]
P2Y4 rat protein [66,68] [66,68] [66,68] [68] [66]
function [67] [67]
P2Y6 rat protein [66,68] [66,68] [66] [68] [68] [66]
P2Y12 rat protein [66] [66] [66] [66]
P2Y14 rat protein [68] [68] [68] [68]
P2 receptor subtypes Presence in the cochlea (P > 15)
Species Detected OHC IHC SGN IBC & IPhC PC DC HC OSC SV RM
P2X1 rat protein [58]
guinea pig protein [40,44]
P2X2 rat mRNA [10,47] [10,47] [10,47,56] [47] [10,47] [10,47] [47] [47] [10] [10,47]
protein [50] [10,58,59] [10] [10,50,59] [50] [50] [58] [10]
mouse protein [41,48] [48] [41] [48] [41,48] [41,48] [48] [48] [41,48]
guinea pig mRNA [51] [51] [51] [51] [51] [51]
protein [37,40,43,44] [37,45] [37] [37] [37]
function [53] [45,53] [53] [54]
P2X3 rat mRNA [56]
protein [58]
P2X4 rat mRNA [56]
protein [58]
guinea pig protein [40,44]
P2X7 rat mRNA [56]
protein [62] [62] [62] [62]
guinea pig protein [40,43,44]
function [55] [55] [55] [55]
P2Y1 rat protein [66] [66] [66]
guinea pig protein [40,44]
P2Y2 rat protein [66] [66]
guinea pig protein [40,44]
P2Y4 rat protein [66,68] [66,68] [66,68] [66] [66]
function [69]
guinea pig protein [40,44] [70] [70]
P2Y6 rat protein [68] [66,68] [66,68] [66] [66]
P2Y12 rat protein [66] [66]
P2Y14 rat protein [68] [68]