Table 3.
Expression of ectonucleotidases in the cochlea before and after hearing onset (P15) in rodents. It includes only subtype and cell specific results. mRNA detection means PCR analysis and in situ hybridization, protein detection means Western-blot analysis and immunohistochemistry, while functional detection indicates pharmacological analysis in electrophysiological or Ca2+ imaging experiments. NTPDases: Ectonucleoside triphosphate diphosphohydrolase isoenzymes; IHC: Inner hair cell; OHC: Outer hair cell; SGN: Spiral ganglion neuron; IBC: Inner boarder cell; IPhC: Inner phalangeal cell; PC: Pillar cell; DC: Deiters’ cell; HC: Hensen’s cell; OSC: Outer sulcus cell; SV: Stria vascularis; RM: Reissner’s membrane.
| Ectonucleotidases | Presence in the Cochlea (P < 15) | |||||||||||
| Species | Detected | OHC | IHC | SGN | IBC & IPhC | PC | DC | HC | OSC | SV | RM | |
| NTPDase5 | rat | protein | [68] | [68] | [68] | [68] | [68] | [68] | [68] | [68] | [68] | |
| NTPDase6 | rat | protein | [68] | [68] | ||||||||
| Ectonucleotidases | Presence in the cochlea (P > 15) | |||||||||||
| NTPDase1 | rat | protein | [77] | [77] | [77] | [77] | [77] | [77] | [78] | |||
| mouse | protein | [78,79,80] | [79,80] | |||||||||
| NTPDase2 | rat | protein | [77] | [77] | [77] | [77,78] | ||||||
| mouse | protein | [80] | [80] | [78] | [80] | |||||||
| NTPDase3 | rat | protein | [81] | [81] | [81] | [81] | [81] | |||||
| NTPDase5 | rat | protein | [68,82] | [82] | [68] | [68,82] | ||||||
| NTPDase6 | rat | protein | [68,82] | |||||||||