Figure 10.

Impact of missense changes on protein folding and correction approaches through chaperone-like compounds. (A) Protein folding in normal conditions assisted by molecular chaperones, with a final production of the native protein conformation. (B) Aberrant folding and the consequent aggregation/degradation of misfolded proteins, unable to reach the native conformation, due to amino acid substitutions caused by missense changes. (C) Rescue of folding of misfolded proteins mediated by chaperone-like compounds.