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LncRNA-miRNA-mRNA networks and autophagy. A decrease in autophagic function is a hallmark of ageing. A variety of stimuli, such as hypoxia or ischemia/reperfusion, oxidized lipoproteins (ox-LDL) or treatment with an MTOR pathway agonist (3BDO), can activate the interaction of lncRNA and miRNA, and the specific modulation of direct and/or indirect targets that, in turn, can affect positively or negatively the autophagic process.
