Table 2.

LDHB-mediated cancer progression.

Cancer Type	Sample/Model System	Mechanism	Expression	Reference
Prostate cancer	poorly metastatic and highly metastatic variant of human prostate cancer cell lines and primary cancer tissues	promoter hypermethylation	loss of LDHB expression	[51]
Gastric cancer cell lines and pancreatic cancer	four gastric cancer cell lines and one pancreatic cancer cell line	promoter hypermethylation	loss of LDHB expression, loss of LDH1-4	[52]
Pancreatic cancer	pancreatic cancer tissues and cell lines	promoter hypermethylation	suppressed LDHB and even total loss	[53]
Breast cancer	breast cancer (adenocarcinoma) tissues and cell lines	promoter hypermethylation	Absent or decreased expression of LDH isoenzymes 1–4	[54]
Breast cancer	basal-like/triple-negative breast cancers	glycolytic pathway	high LDHB expression	[55]
Hepatocellular carcinoma	Highly metastatic cell line	Metastasis potential	down-regulated LDHB expression	[56]
Hepatocellular carcinoma	HCC cancer tissues	unfavorable survival outcomes	Low LDHB expression	[57]
Urinary bladder urothelial carcinoma (UBUC)	UBUC cancer tissues	tumor progression and inferior disease-specific survival	Loss of LDHB expression	[58]
Colorectal cancer	colorectal cancer tissues, in vitro and in vivo model	increased autophagy, accelerated cancer growth mediated by SIRT5/LDHB pathway	Deacetylation of LDHB	[61]
Colorectal cancer	colorectal cancer tissues, CRC cell lines,	RPS7 mediated cell glycolysis inhibition, inhibits colorectal cancer growth	Suppressed LDHB expression	[62]
Hepatoma cancer	hepatoma cell lines	claudin-1-mediated high invasive activity	Decreased LDHB expression	[63]
Colorectal cancer	stage I-III CRC patient samples, in vitro	KLF14 regulates glycolysis	downregulating LDHB expression	[64]
Lung cancer	KRAS-dependent lung adenocarcinoma samples, vitro and in vivo	predictor of shorter survival in patients, KRAS-mutant lung tumors are more dependent on glycolysis for proliferation compared with KRAS wild-type lung tumors	high LDHB expression	[65]