Table 2.
IC50 values in μM for terrosamycin A (1) and B (2) and the polyether standards against methicillin-resistant Staphyloccocus aureus (MRSA), vancomycin resistant Enterococcus faecium (VRE) and S. warneri. Data are reported as the average ± SE (n = 6).
| Compound | MRSA | VRE | S. warneri |
|---|---|---|---|
| terrosamycin A (1) | 0.5 ± 0.2 | 0.58 ± 0.04 | 0.9 ± 0.3 |
| terrosamycin B (2) | 0.34 ± 0.04 | 0.5 ± 0.1 | 0.7 ± 0.1 |
| salinomycin (3) | 0.4 ± 0.1 | 0.8 ± 0.2 | 0.9 ± 0.2 |
| monensin (4) | 1.5 ± 0.1 | 8 ± 5 | 2.0 ± 0.2 |
| nigericin (5) | 0.2 ± 0.1 | 0.5 ± 0.1 | 0.3 ± 0.1 |
| vancomycin control | 0.8 ± 0.1 | - | 0.53 ± 0.01 |
| rifampicin control | - | 1.1 ± 0.1 | - |