Table 3.
IC50 values in μM for terrosamycin A (1) and B (2) and polyether standards against two breast cancer cell lines (HTB-26, MCF-7) and two healthy cell lines (Vero, BJ). Data are reported as the average ± SE (n = 3).
| Compound | HTB-26 | MCF-7 | Vero | BJ |
|---|---|---|---|---|
| terrosamycin A (1) | 10.1 ± 0.6 | 6 ± 1 | 36 ± 6 | 79 ± 5 |
| terrosamycin B (2) | 6 ± 1 | 3.9 ± 0.4 | 93 ± 4 | 267 ± 28 |
| salinomycin (3) | 13 ± 1 | 10 ± 3 | 78 ± 22 | 196 ± 3 |
| monensin (4) | 10 ± 1 | 7 ± 2 | 1E4 ± 1E3 | 245 ± 11 |
| nigericin (5) | 13 ± 2 | 9 ± 3 | 61 ± 8 | 221 ± 10 |
| doxorubicin control | 4 ± 2 | 0.8 ± 0.1 | - | - |