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Proposed role of bone matrix Dickkopf–1 (DKK1) and sclerostin (SOST) in postmenopausal osteoporosis. (A) DKK1 and SOST are produced by osteoblasts or osteocytes during active canonical wingless (Wnt) signaling and stored in bone. (B) during bone resorption these are released and during excessive resorption they may (C) inhibit osteoblasts to the extent that they cannot replace the resorption lacunae.
