Figure 3.

The multi-level effect of 6-gingerol (5-hydroxy-1-(4′-hydroxy3′-methoxyphenyl)-3-decanone) on cancer cells. Apaf-1—Apoptotic protease activating factor, Ap-1—Activator protein 1, Apaf-1—Apoptotic protease activating factor 1, Bax—BCL2 associated X protein, bFGF—basic fibroblast growth factor, COX-2—Prostaglandin-endoperoxide synthase 2, EGF—Epidermal growth factor, iNOS—Nitric oxide synthases, IκBα—Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, MITF—Microphthalmia-associated transcription factor, NFκB—Nuclear factor kappa-light-chain-enhancer of activated B cells, p-AKT—Protein kinase B (phosphorylated), VEGF—Vascular endothelial growth factor.