Table 1.

Summary of the phenotypic effects of knockout mice for RAR genes.

	Hematopoietic Cell Population	Bone Marrow Phenotype	Bone Marrow Defects	Reference
Rara−/− mice	normal granulocyte population normal HSCs numbers and function	normal development	manifold defects in several tissues high post-natal mortality	[97,132,133]
Rarb−/− mice	normal development	normal development	none	[131]
Rarg−/− mice	↑ granulocytes in PB, BM and spleen several defects both in erythropoiesis and B lymphopoiesis	↑osteoclastogenesis ↓ trabecular bone mass	manifold defects in several tissues high post-natal mortality	[132,133,134,135,137]
Nestin-Cre: Rarg Δ/Δ mice	impaired BM B lymphopoiesis and thymic T lymphopoiesis normal HSCs numbers and function	NA	/	[102]
Prrx1:RargΔ/Δ female mice	↑ BM granulocytes	↑ trabecular osteoblasts	enhanced BM vascularization: ↑ expression of Vegf-a	[127]
Prrx1:RargΔ/Δ male mice	↑ pro-B and pre-B lymphocytes in BM unchanged number of splenic and mature PB B lymphocytes	↑ trabecular osteoclasts	enhanced BM vascularization: ↑ expression of Vegf-a	[127]