Figure 2.

Impairments to conventional and monocyte-derived dendritic cell function in leukemia. DCs exhibit reduced capacity to stimulate T cells in different subsets of leukemia via reduced co-stimulatory molecule expression (Chronic Myeloid Leukemia (CML), Acute Myeloid Leukemia (AML)) [48,51], increased expression of anti-inflammatory cytokines (CLL, AML) [52,72], aberrant actin organization and reduced antigen uptake (CML) [33], disruption of LPS in vitro response through increased SOCS5 expression (CLL) [72], as well as defective differentiation from HSCs (ALL, CLL) or leukemic blasts (AML, CML). IDO1: indoeamine 2,3 dioxygenase. LPS: Lipopolysaccharide. PD-1: Programmed-Death-1. TLR: Toll-like Receptor.