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Structure of anti-rat transferrin receptor monoclonal antibody (TfRMAb) engineered to deliver methotrexate (MTX) to the brain by exploiting transferrin receptor-mediated transcytosis. The TfRMAb-MTX conjugate in this example was prepared by oxidation of the carbohydrate groups located on the Fc portion of the TfRMAb to form an aldehyde derivative, which was treated with a hydrazide-functionalized MTX forming a hydrazone-linker between MTX and TfRMAb.
