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Recruitment of HDAC to retinoic acid-responsive elements (RARE) in Promyelocytic leukemia (PML). HDAC forms a multiprotein complex with RAR-PLZF, resulting in the transcriptional repression of retinoic acid receptor (RAR) target gene, responsible for normal differentiation and proliferation of myeloid cells. HDACi can reverse this case by restoring the sensitivity of PML to retinoic acids.
