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. 2019 Jun 19;20(12):2992. doi: 10.3390/ijms20122992

Figure 1.

Figure 1

Effects of sildenafil on cGMP and cAMP concentrations in HepG2 cells. (A) Intracellular cGMP and (B) intracellular cAMP concentrations in HepG2 cells treated with sildenafil (10 nM to 100 µM) for 30 min. Data were calculated and statistically analyzed as fold change of control and are expressed as means ± SEM (n = 3 to 6, p ≤ 0.05) (absolute values for control means are 1.642 pmol cGMP/mg protein and 3.45 pmol cAMP/mg protein). (C) Comparison of cAMP response in HepG2 cells treated with sildenafil (10 nM to 10 µM) +/− PDE2 inhibitor (BAY 60-7550, 10 uM) for 30 min.