Table 1.

List of relevant nutrition-sensitive DNA methylation loci in humans and model organisms.

Dietary Condition	DNA Methylation Regulated Locus(i)	Sample Type(s)	Species	References
Low protein diet	GR, PPARα, Hnf4a, Nyp, Pomc	Liver, pancreatic islets, hypothalamus	Rat	[40,41,43,44]
	Lxrα, Lep	Liver, adipose tissue	Mouse	[42,45]
Caloric restriction	IGF2/H19	Adrenal gland	Sheep	[47]
	PCK1	Fetal liver	Baboon	[49]
	IGF2, INSIGF2, GNASAS1, MEG3, IL-10, LEP	Blood	Human	[50,51]
	WT1, TNF-α	Blood	Human	[53,54]
	PPARGC1A	Skeletal muscle	Human	[56]
	ADIPOQ, LEP	Adipose tissue	Human	[57]
High-fat feeding	Fgf21	Liver	Mouse	[61]
	Scd1	Adipose tissue	Rat	[63]
	Ankrd26, Hoxa5	Adipose tissue	Mouse	[15,65]