Table 1.
Examples of factors involved in antibiotic production in Streptomyces spp. that are linked to stress response or GTP synthesis.
| Species | Factor | Link to Guanosine Metabolism or Antibiotic Production |
|---|---|---|
| S. coelicolor | RelA | (p)ppGpp synthesis, ACT/RED production [64] |
| S. coelicolor | RelC (RplK) | (p)ppGpp synthesis, ACT/RED production [68] |
| S. coelicolor | EshA | (p)ppGpp synthesis, ACT production [67] |
| S. coelicolor | XdhR | Xdh and (p)ppGpp synthesis, ACT production [51,56,58] |
| S. coelicolor | RmdA, RmdB | c-di-GMP degradation, ACT production [30] |
| S. coelicolor | CdgA, CdgB | c-di-GMP synthesis, ACT production [31] |
| S. antibioticus | RelA | (p)ppGpp synthesis, actinomycin production [69] |
| S. antibioticus | RelC | (p)ppGpp synthesis, actinomycin production [70] |
| S. clavuligerus | RelA | (p)ppGpp synthesis, clavulanic acid and cephamycin C production [27,71] |
| S. griseus | Rel GuaA |
(p)ppGpp synthesis, streptomycin production [23] |