Table 1.
Known vascular endothelial growth factor (VEGF) polymorphisms and genes associated with VEGF pathways.
| Gene cDNA Position | rs | Study Annotation | Ref |
|---|---|---|---|
| VEGF − 2578C > A | rs699947 | The AA genotype is associated with higher overall survival in patients receiving combined paclitaxel/bevacizumab | [36] |
| VEGF − 1154G > A | rs1570360 | ||
| VEGF-A Ex1 − 73C > T | rs25648 | The TT, AA, TT, and TT genotypes are associated with an increased risk of bladder cancer | [37] |
| VEGF-A − 15648A > C | rs833052 | ||
| VEGF-A − 9228G > T | rs1109324 | ||
| VEGF-A − 8339A > T | rs1547651 | ||
| VEGF-A IVS2 + 1378C > T | rs3024994 | Associated with reduced bladder cancer risk | [37] |
| NOS3 − 786TT | rs2070744 | Associated with metastatic breast cancer | [38] |
| NOS3 894GG | rs1799983 | [38] |