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RANK, RANKL and OPG mRNA expressions are elevated in OC tissue, particularly in BRCA1/2 mutated OC. (A) RANKL, (B) OPG and (C) RANK expression in non-malignant ovaries (n = 21), non-malignant fallopian tubes (n = 14) and OC (n = 192). (D) RANKL mRNA expression in BRCA1/2 mutated (mut) OC (n = 44) compared to BRCA1/2 wild-type (wt) tumours (n = 146). RANK, RANKL and OPG mRNA expression values were normalized to TBP expression, n.s., not significant.
