Table 1.
List of polyphenolic compounds and intestinal microbiota-generated metabolites included in the screening regarding their effects on phosphorylation of Akt at Ser473 site. Classification according to Zhang et al. 2016 [2].
| Chemical Subclass | Individual Compounds | Number |
|---|---|---|
| Flavones * | Luteolin *, apigenin, flavone, 6-hydroxyflavone, 3-hydroxyflavone, 6-methoxyflavone, 7-methoxyflavone, 7,8-dihydroxyflavone, chrysin, baicalein, baicalin, 3-methoxyflavone, 3,4′-dihydroxyflavone, 3-hydroxy-4′-methoxyflavone, vitexin, wogonoside | 16 |
| Flavon-3-ols (Flavonols) | quercetin, fisetin, kaempferol, myricetin, morin | 5 |
| Stilbenoids | resveratrol, pinostilbene, pterostilbene, 3,4′5-trimethoxy-trans-stilbene, piceatannol | 5 |
| Flavan-3-ols (Flavanols) | (+)-catechin, taxifolin, (−)-epicatechin, (−)-epicatechin gallate, (−)-epigallocatechin gallate, (−)-gallocatechin gallate | 6 |
| Isoflavones | genistein | 1 |
| Flavanones | naringenin | 1 |
| Phenolic acids | caffeic acid, trans-ferulic acid, chlorogenic acid | 3 |
| Catechin metabolites | M1, M2 | 2 |
| Ellagic acid and its metabolites | ellagic acid, urolithin A, B, C, D | 5 |
* Subclasses and representatives, which were additionally investigated by Western blot analysis, are marked in bold.