Table 2.
Summary of the semi-quantitative structure-activity relationships of flavones/flavonols and stilbenoids regarding pAkt inhibition.
| Structural Features | Possible Effect | Evidence | |
|---|---|---|---|
| Flavones/Flavon-3-ols | |||
| 1 | C2=C3 double bond (Ring C) | Essential | Quercetin/Taxifolin; Apigenin/Naringenin |
| 2 | OH-groups (Ring B) (m-, p-) | Contribution | Luteolin (m, p) > Apigenin (p) > Chrysin (Ø) |
| 3 | 3-p. (Ring C): hydroxylation | Reduction | Luteolin/Quercetin; Apigenin/Kaempferol |
| 4 | Glycosylation | Abolishment | Apigenin/Vitexin; Baicalein/Baicalin |
| Stilbenoids | |||
| 1 | Three free OH-groups | Optimal | Resveratrol > Pinostilbene > Pterostilbene ≈ 3,4′,5-trimethoxy-trans-stilbene |
| 2 | Methylation of OH-groups | Abolishment | |