Table 3.
Comparison of the proposed structure-activity features regarding inhibitory effects on Akt-phosphorylation (pAkt) determined in the present study with the antioxidant properties of polyphenols [43].
| Functional Characteristic | Inhibition of pAkt | Antioxidant Activity |
|---|---|---|
| Double bond (C2=C3) | Increase | Increase |
| OH-group in ring A | Increase | Increase |
| OH-group in ring B | Increase | Increase |
| OH-group in ring C (3-OH) * | Decrease | Increase |
| Glycosyl group * | Abolish/Reverse | Decrease |
| O-Methyl group | Decrease | Decrease |
* Functional groups entailing divergent effects are marked in bold and red.