Table 1. PAR2-Targeted Peptides (1, 2, and 6–12) with Their EC₅₀ and LogD Values^a.

#	compound	EC50 (nM)	pEC50 ± SEM	LogD ± SEM
1	SLIGRL-NH2	7144	5.15 ± 0.03	–1.02 ± 0.02
2	2f-LIGRLO-NH2	210	6.68 ± 0.04	–1.06 ± 0.01
6	Isox-Cha-Chg-NH2	2555	5.59 ± 0.10	2.00 ± 0.02
7	Isox-Cha-Chg-AR-NH2	14	7.86 ± 0.06	–0.15 ± 0.01
8	Isox-Cha-Chg-AR-NH(CH2)6NH2	16	7.79 ± 0.04	–0.40 ± 0.01
9	Isox-Cha-Chg-ARLK-NH2	23	7.65 ± 0.07	–0.72 ± 0.02
10	Isox-Cha-Chg-ARAK-NH2	15	7.82 ± 0.07	–1.58 ± 0.04
11	Isox-Cha-Chg-ARK-NH2	10	8.00 ± 0.09	–0.86 ± 0.02
12	Isox-Cha-Chg-ARK(COCH3)-NH2	16	7.78 ± 0.05	–0.24 ± 0.02

^aEC₅₀ values determined through a dose–response curve from a β-arrestin 2 recruitment assay in HEK293T cells transiently transfected with PAR2-eYFP/Arr2-rluc BRET pair (n ≥ 3). LogD values were determined at a physiological pH of 7.4 (n = 3).