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Selectivity of eight compounds 12, 13, 18, 19 (DL5050), 23, 26, 29, and CITCO (1) for hCAR over hPXR. (A) Dose-dependent activation of hCAR by CITCO, 12, 13, 18, 19, 23, 26, and 29 in high throughput hCAR agonist luciferase gene reporter assays. (B) Dose-dependent activation of hPXR by CITCO, 12, 13, 18, 19, 23, 26, and 29 in high throughput hPXR agonist luciferase gene reporter assays.
