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. 2019 Jun 12;10(7):1039–1044. doi: 10.1021/acsmedchemlett.9b00079

Figure 4.

Figure 4

hCAR regulated induction of CYP2B6 and CYP3A4 in HPHs. (A) CYP2B6 and CYP3A4 mRNA levels were measured in HPHs prepared from human liver donors (HL-#151). The HPHs were treated with CITCO (0.5, 1, and 5 μM), PB (1 mM), RIF (10 μM), DL5050 (0.5, 1, and 5 μM), 18 (0.5, 1, and 5 μM), or vehicle control. (B) Representative immunoblots of CYP2B6 and CYP3A4 proteins in HPHs from liver donors #151. RT-PCR data obtained from three independent experiments were expressed as mean ± SD normalized against vehicle control.