Skip to main content
. 2019 Jun 20;8(6):620. doi: 10.3390/cells8060620

Figure 1.

Figure 1

Janus kinase (JAK)/signal transducer and activators of transcription (STAT) pathway of cytokine action. Cytokines bind to receptors embedded in the cell surface, triggering the activation of one or more JAKs. The JAK then phosphorylates the receptors, and when the STATs bind, they are phosphorylated by receptors. Once the STAT is phosphorylated, it acts on the transcription and translation of DNA within the nucleus to regulate gene expression. The cell will then induce a signalling pathway, upregulate or downregulate more cytokines, or activate other cell types [26,27].