Table 1.
An offspring’s sex influences mitochondrial dynamism and morphology in neonatal rat cardiomyocytes.
| Event | Offspring Group | Female Mean (SEM) |
Male Mean (SEM) |
p-Value |
|---|---|---|---|---|
| Fusion | Controls | 1.03 (0.12) | 0.82 (0.14) | 0.31 |
| (events/100 μm2/5 min) | Diabetes exposed | 0.53 (0.13) | 0.39 (0.06) | 0.42 |
| Diet exposed | 0.35 (0.05) | 0.58 (0.08) | 0.04 * | |
| Combination exposed | 0.58 (0.10) | 0.42 (0.06) | 0.18 | |
| Fission | Controls | 0.98 (0.16) | 0.84 (0.11) | 0.46 |
| (events/100 μm2/5 min) | Diabetes exposed | 0.66 (0.06) | 0.64 (0.05) | 0.72 |
| Diet exposed | 0.52 (0.03) | 0.48 (0.05) | 0.47 | |
| Combination exposed | 0.42 (0.13) | 0.49 (0.02) | 0.55 | |
| Fission:Fusion | Controls | 0.91 (0.09) | 1.14 (0.17) | 0.40 |
| (Ratio) | Diabetes exposed | 1.87 (0.48) | 1.80 (0.30) | 0.68 |
| Diet exposed | 1.71 (0.13) | 0.88 (0.16) | 0.06 | |
| Combination exposed | 0.77 (0.19) | 1.27 (0.05) | 0.02 * | |
| Length | Controls | 5.26 (0.26) | 5.08 (0.36) | 0.73 |
| (μm) | Diabetes exposed | 4.17 (0.20) | 4.36 (0.30) | 0.58 |
| Diet exposed | 4.53 (0.32) | 4.41 (0.23) | 0.79 | |
| Combination exposed | 3.88 (0.26) | 4.15 (0.22) | 0.44 | |
| Width | Controls | 0.59 (0.03) | 0.73 (0.03) | 0.008 * |
| (μm) | Diabetes exposed | 0.76 (0.03) | 0.85 (0.03) | 0.06 |
| Diet exposed | 0.83 (0.03) | 0.88 (0.04) | 0.37 | |
| Combination exposed | 0.77 (0.05) | 0.77 (0.05) | 0.41 |
NRCM, neonatal rat cardiomyocytes. Significant differences (p ≤ 0.05) between female and male offspring by t-test are indicated by boldface and *.