Table 2.
Top canonical pathways regulated by PXDN.
| Top Canonical Pathways | |||
|---|---|---|---|
| Name | p-Value | Overlap | Molecules from DE Proteins in PXDN KD Experiment in Pathway |
| NRF2-mediated Oxidative Stress Response | 2.49 × 10−8 | 8.3% (15/180) | GSTA3,PPIB,PRDX1,GSTM3,NQO1,SOD1,TXNRD1,ERP29, STIP1,MAPK3,CAT,TXN,FKBP5,CBR1,EPHX1 |
| phagosome maturation | 1.27 × 10−6 | 8.7% (11/127) | NSF,CALR,TUBA1B,PRDX1,TUBB4B,RAB7A,CANX,TUBB4A, TUBB,PRDX6,PRDX2 |
| EIF2 Signaling | 1.71 × 10−6 | 7.0% (13/187) | RPS28,EIF1,RPLP1,RPL13,RPL3,MAPK3,RPS27L,RPLP2,RPS10, RPS3,RPS12,RPL7,EIF3K |
| Mitochondrial Dysfunction | 1.82 × 10−6 | 6.9% (13/188) | SDHA,PRDX3,NDUFA5,NDUFA6,CAT,UQCRC2,CYCS,VDAC1, OGDH,NDUFS3,NDUFAB1,COX4I1,VDAC2 |
| Gluconeogenesis I | 2.63 × 10−6 | 15.2% (7/46) | PGK1,PGAM1,ALDOA,GAPDH,MDH1,MDH2,ALDOC |