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. 2019 Jun 12;20(12):2860. doi: 10.3390/ijms20122860

Figure 3.

Figure 3

Ire1p domains, domain-specific theoretical isoelectric point (pI), and hydrophobicity [70] along the protein (sliding window of 10 amino acids). N: N-terminal domain; cLD: core luminal domain; TM: transmembrane domain; Linker: positively charged linker domain; Kinase: Kinase domain; RNase: RNase domain. The red arrow points to a highly hydrophobic stretch near the N-terminus that needs to be either buried deep into the folded Ire1p or insert into a membrane. Results generated from DAMBE [71].