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. 2019 Jun 19;20(12):3005. doi: 10.3390/ijms20123005

Figure 5.

Figure 5

Effect of AMPKα2 deletion in myeloid cells on atherosclerotic plaque formation. ApoExα2fl/fl (fl/fl) and ApoExα2∆MC (∆MC) mice were fed a western diet for four months. (A) Representative pictures of oil red O stained dissected aortae and quantification of the plaque area; n = 7 to 10 animals per group (Student’s t test). (B) Cholesterol levels in serum from ApoExα2fl/fl (fl/fl) and ApoExα2∆MC (∆MC) fed a western diet for four months; n = 8 to 10 animals per group (Student’s t-test). (C) Mac2 (blue) and smooth muscle actin (green) expression in aortic root plaques from ApoExα2fl/fl (fl/fl) and ApoExα2∆MC (∆MC) mice, DAPI = grey; plaques from n = 7–10 mice per group. Size bar = 100 µm (Student’s t test). (D) MMP9 (red) expression in aortic root plaques from ApoE-/- (fl/fl) and ApoExα2∆MC (∆MC) mice, DAPI = grey; n = 5 to 6 animals per group. Size bar = 100 µm (Student’s t-test). * p < 0.05.