Table 1.
Analysis of the response of basal-like and non-basal like HNSCC cell lines to treatment with Afatinib, Erlotinib, Cetuximab, Gedatolisib, Cobimetinib, and Trastuzumab. Cell line names and subgroup (basal versus non-basal), drug names, and AUC are shown.
| Cell Line | Molecular Subtype | AUC | |||||
|---|---|---|---|---|---|---|---|
| Afatinib | Erlotinib | Cetuximab | Gedatolisib | Cobimetinib | Trastuzumab | ||
| BHY | Basal | 3.467751696 | 4.286063175 | 4.57727436 | 3.302462568 | 4.608746135 | 4.69416933 |
| CAL27 | Basal | 3.814815676 | 4.444098626 | 5.680773203 | 3.184901695 | 3.747852593 | 5.5725818 |
| CAL33 | Basal | 3.744753557 | 4.310451267 | 4.573913673 | 2.406624054 | 4.450866901 | 5.076910559 |
| HSC2 | Basal | 4.3439915 | 4.741863856 | 5.127815501 | 2.566283234 | 4.420333039 | 4.946942339 |
| HSC3 | Basal | 3.957972571 | 4.6095489 | 5.183631235 | 2.952916999 | 3.8894347 | 5.295803542 |
| KYSE150 | Basal | 4.441065136 | 4.780103002 | 5.684081754 | 2.980021031 | 4.687959978 | 5.550264191 |
| SCC15 | Basal | 4.315046458 | 4.766164343 | 4.54432253 | 3.764267942 | 4.6050741 | 5.494692438 |
| SCC25 | Basal | 4.177447191 | 4.336103828 | 5.446338918 | 2.771755456 | 3.798183465 | 5.231781001 |
| SCC4 | Basal | 4.019642792 | 5.002304825 | 5.305982451 | 2.737492906 | 4.32226842 | 5.256117469 |
| SCC9 | Basal | 4.134972926 | 4.713456974 | 5.222760141 | 3.005065893 | 4.873465213 | 4.87701988 |
| KYSE270 | Non-Basal | 3.805157987 | 5.500896683 | 5.647765664 | 3.332916543 | 5.232659439 | 5.565586558 |
| KYSE180 | Non-Basal | 4.01491891 | 4.729217951 | 5.705364107 | 3.147861975 | 4.918800553 | 5.272014082 |
| TE6 | Non-Basal | 4.258968922 | 4.879974238 | 5.750123119 | 3.639308374 | 5.517244329 | 4.979449358 |
| TE5 | Non-Basal | 3.9331781 | 5.159062006 | 5.461107055 | 2.778634257 | 4.731403338 | 5.23314044 |
| TE10 | Non-Basal | 4.006096215 | 5.513704267 | 5.222443794 | 3.497187601 | 4.890993502 | 4.946552101 |
| KYSE140 | Non-Basal | 3.375761348 | 4.562986869 | 5.376787765 | 2.919235293 | 4.740974506 | 5.268327679 |
| KYSE510 | Non-Basal | 4.845901636 | 5.515376689 | 5.879640984 | 3.013249683 | 5.011478461 | 5.476614796 |
| RPMI2650 | Non-Basal | 4.780339567 | 5.726684777 | 6.149644208 | 3.600359879 | 5.476229419 | 5.540633467 |
| LB771HNC | Non-Basal | 4.793902186 | 5.152157915 | 5.694559888 | 3.158211825 | 5.585646234 | 5.618555173 |
| HCE4 | Non-Basal | 4.424539135 | 5.687089202 | 5.91969998 | 3.64854173 | 4.638847027 | 5.069966605 |
| KYSE70 | Non-Basal | 4.46079496 | 4.986291447 | 5.50519843 | 3.657912306 | 4.8211094 | 5.244702124 |
| TE4 | Non-Basal | 1.814915762 | 3.96069768 | 5.420791576 | 2.170670697 | 4.2463357 | 5.08505704 |
| TE14 | Non-Basal | 3.746428006 | 4.638733677 | 5.619299993 | 3.187628054 | 4.881707599 | 4.869384943 |
| TT | Non-Basal | 4.822344476 | 4.872688138 | 6.220243167 | 3.678272613 | 4.728732451 | 5.642166616 |
| HSC4 | Non-Basal | 3.655491187 | 4.180726139 | 4.651136469 | 2.751213387 | 3.871130995 | 5.136060907 |