Table 2.
Evaluation of the therapeutic efficiency of drug combinations, as determined by Bliss synergy scoring models. The Bliss score for each drug combination is shown for the 25 HNSCC cell lines.
| Cell Line | Molecular Subtype | Bliss Synergy Score | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Afatinib Cobimetinib | Afatinib Gedatosilib | Afatinib Trastuzumab | Cetuximab Cobimetinib | Cetuximab Gedatosilib | Cetuximab Trastuzumab | Erlotinib Cobimetinib | Erlotinib Gedatosilib | Erlotinib Trastuzumab | ||
| BHY | Basal | 3.777 | 5.658 | −0.348 | 7.32 | 5.569 | 13.195 | 4.33 | 4.807 | 1.701 |
| CAL27 | Basal | 6.881 | 6.787 | 6.243 | 4.252 | 3.649 | 18.943 | −0.354 | 0.38 | −0.958 |
| CAL33 | Basal | 1.89 | 0.267 | 5.684 | 0.134 | 4.621 | 12.537 | −4.981 | 2.219 | −2.872 |
| HSC2 | Basal | −4.527 | 4.403 | NA | NA | 3.066 | NA | −0.745 | 2.266 | 4.648 |
| HSC3 | Basal | −3.278 | 3.889 | 7.754 | 0.688 | 4.096 | NA | 0.517 | 1.721 | −0.263 |
| KYSE150 | Basal | −0.552 | 2.649 | NA | 5.502 | −0.469 | −0.595 | −1.648 | −0.445 | 1.263 |
| SCC4 | Basal | 5.145 | 4.867 | 2.687 | 1.146 | 0.522 | 2.728 | 2.702 | 2.979 | −1.275 |
| SCC9 | Basal | −3.499 | 6.269 | NA | −1.755 | 1.367 | NA | −1.792 | 2.185 | NA |
| SCC15 | Basal | −3.148 | 3.646 | 14.661 | 5.549 | −0.535 | NA | −1.593 | 0.959 | 6.95 |
| SCC25 | Basal | 2.244 | 3.184 | NA | 3.195 | NA | NA | −0.986 | −2.037 | NA |
| HCE4 | Non-Basal | −2.168 | −0.69 | 2.283 | 0.468 | NA | −2.688 | 4.937 | −0.317 | 4.016 |
| HSC4 | Non-Basal | −1.389 | 1.218 | 3.527 | −0.705 | 6.87 | 4.059 | −5.899 | −1.913 | −3.647 |
| KYSE70 | Non-Basal | 0.059 | 3.988 | 0.633 | −2.264 | 1.621 | 1.546 | 0.589 | −1.169 | −1.116 |
| KYSE140 | Non-Basal | 3.049 | 0.646 | 7.26 | 10.795 | NA | 6.541 | 0.466 | −2.501 | 5.82 |
| KYSE180 | Non-Basal | 1.067 | 2.902 | NA | 3.957 | 2.78 | NA | 1.759 | 3.795 | NA |
| KYSE270 | Non-Basal | −4.853 | 0.576 | −1.243 | NA | 1.923 | −2.788 | 1.111 | −1.681 | −3.602 |
| KYSE510 | Non-Basal | −0.962 | 6.481 | −1.99 | 0.86 | −0.325 | 2.142 | 1.738 | 4.474 | 6.968 |
| LB771HNC | Non-Basal | 3.722 | −0.689 | 0.706 | 7.077 | NA | NA | −3.277 | 0.658 | −1.902 |
| RPMI2650 | Non-Basal | −2.515 | 4.699 | −4.25 | NA | NA | NA | NA | NA | NA |
| TT | Non-Basal | 1.248 | 0.669 | 3.563 | 7.21 | −0.107 | 0.137 | 7.854 | 1.774 | −3.544 |
| TE4 | Non-Basal | 6.516 | 4.268 | 3.194 | −4.664 | 1.476 | −0.945 | 3.363 | 1.593 | 7.991 |
| TE5 | Non-Basal | 1.231 | 1.934 | −2.293 | −2.822 | 3.753 | 6.738 | −1.631 | 4.127 | 7.413 |
| TE6 | Non-Basal | NA | −0.834 | 5.833 | 0.528 | 2.57 | NA | −1.479 | −0.38 | 4.62 |
| TE10 | Non-Basal | 4.294 | −0.084 | −1.468 | −6.371 | −3.032 | NA | 0.085 | 0.77 | −1.671 |
| TE14 | Non-Basal | 5.072 | 2.447 | 5.155 | −5.61 | 1.86 | 5.379 | −2.549 | −1.334 | 10.887 |