Table 2.
Cell Line | Molecular Subtype | Bliss Synergy Score | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Afatinib Cobimetinib | Afatinib Gedatosilib | Afatinib Trastuzumab | Cetuximab Cobimetinib | Cetuximab Gedatosilib | Cetuximab Trastuzumab | Erlotinib Cobimetinib | Erlotinib Gedatosilib | Erlotinib Trastuzumab | ||
BHY | Basal | 3.777 | 5.658 | −0.348 | 7.32 | 5.569 | 13.195 | 4.33 | 4.807 | 1.701 |
CAL27 | Basal | 6.881 | 6.787 | 6.243 | 4.252 | 3.649 | 18.943 | −0.354 | 0.38 | −0.958 |
CAL33 | Basal | 1.89 | 0.267 | 5.684 | 0.134 | 4.621 | 12.537 | −4.981 | 2.219 | −2.872 |
HSC2 | Basal | −4.527 | 4.403 | NA | NA | 3.066 | NA | −0.745 | 2.266 | 4.648 |
HSC3 | Basal | −3.278 | 3.889 | 7.754 | 0.688 | 4.096 | NA | 0.517 | 1.721 | −0.263 |
KYSE150 | Basal | −0.552 | 2.649 | NA | 5.502 | −0.469 | −0.595 | −1.648 | −0.445 | 1.263 |
SCC4 | Basal | 5.145 | 4.867 | 2.687 | 1.146 | 0.522 | 2.728 | 2.702 | 2.979 | −1.275 |
SCC9 | Basal | −3.499 | 6.269 | NA | −1.755 | 1.367 | NA | −1.792 | 2.185 | NA |
SCC15 | Basal | −3.148 | 3.646 | 14.661 | 5.549 | −0.535 | NA | −1.593 | 0.959 | 6.95 |
SCC25 | Basal | 2.244 | 3.184 | NA | 3.195 | NA | NA | −0.986 | −2.037 | NA |
HCE4 | Non-Basal | −2.168 | −0.69 | 2.283 | 0.468 | NA | −2.688 | 4.937 | −0.317 | 4.016 |
HSC4 | Non-Basal | −1.389 | 1.218 | 3.527 | −0.705 | 6.87 | 4.059 | −5.899 | −1.913 | −3.647 |
KYSE70 | Non-Basal | 0.059 | 3.988 | 0.633 | −2.264 | 1.621 | 1.546 | 0.589 | −1.169 | −1.116 |
KYSE140 | Non-Basal | 3.049 | 0.646 | 7.26 | 10.795 | NA | 6.541 | 0.466 | −2.501 | 5.82 |
KYSE180 | Non-Basal | 1.067 | 2.902 | NA | 3.957 | 2.78 | NA | 1.759 | 3.795 | NA |
KYSE270 | Non-Basal | −4.853 | 0.576 | −1.243 | NA | 1.923 | −2.788 | 1.111 | −1.681 | −3.602 |
KYSE510 | Non-Basal | −0.962 | 6.481 | −1.99 | 0.86 | −0.325 | 2.142 | 1.738 | 4.474 | 6.968 |
LB771HNC | Non-Basal | 3.722 | −0.689 | 0.706 | 7.077 | NA | NA | −3.277 | 0.658 | −1.902 |
RPMI2650 | Non-Basal | −2.515 | 4.699 | −4.25 | NA | NA | NA | NA | NA | NA |
TT | Non-Basal | 1.248 | 0.669 | 3.563 | 7.21 | −0.107 | 0.137 | 7.854 | 1.774 | −3.544 |
TE4 | Non-Basal | 6.516 | 4.268 | 3.194 | −4.664 | 1.476 | −0.945 | 3.363 | 1.593 | 7.991 |
TE5 | Non-Basal | 1.231 | 1.934 | −2.293 | −2.822 | 3.753 | 6.738 | −1.631 | 4.127 | 7.413 |
TE6 | Non-Basal | NA | −0.834 | 5.833 | 0.528 | 2.57 | NA | −1.479 | −0.38 | 4.62 |
TE10 | Non-Basal | 4.294 | −0.084 | −1.468 | −6.371 | −3.032 | NA | 0.085 | 0.77 | −1.671 |
TE14 | Non-Basal | 5.072 | 2.447 | 5.155 | −5.61 | 1.86 | 5.379 | −2.549 | −1.334 | 10.887 |