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. 2019 May 31;11(6):763. doi: 10.3390/cancers11060763

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) experimental design to generate prostate cancer metastasis in humanized bone/BM ossicles. (A) PC-3 and RWPE-1 cells were i.c. or i.v. injected in mice bearing heterotopic ossicle; (B) radiographic images were not indicative of mice skeleton tumor cell colonization, and histological analyses confirmed the absence of tumor cells in all examined bone tissues; (C) only PC-3 cells could generate metastases and only in ectopic humanized bone/BM ossicles (a–f, arrows). H&E, Hematoxylin/Eosin; ft, fibrous tissue; s, sinusoid HA/TCP particles (HAC), hematopoietic cells (hem). Scale bars = 300 μm, 500 μm.