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. 2019 May 31;11(6):763. doi: 10.3390/cancers11060763

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PC3 cells localization in extraskeletal bone/marrow ossicles and foci of cancer cells occupied a perisinusoidal position. In heterotopic transplants, single cancer cells can be observed inside sinusoids (a), wrapped around the outer surface of sinusoids (b) or near sinusoids, in the space between the vessel and bone (c). Early metastatic deposits were regularly associated with sinusoids and with the surfaces of bone or carrier particles (d,e). Intra-cardiac injected PC3 cells generated massive metastases in transplants (f,g). PC-3 metastases were identified by immunolabelling for human CD146 in ectopic marrow ossicles (h,i). HA/TCP particles (HAC), hematopoietic cells (hem); H&E, Hematoxylin/Eosin; OCs, osteoclasts; S, sinusoid. Scale bar = 40, 70, 80, 100 μm.