Table 2.
Comparison of ARMS and SABER/MassARRAY methods in detecting exon 19 deletions EGFR mutations from ctDNA.
| Exon 19 deletions ARMS vs. Tissue | |||
|---|---|---|---|
| ARMS | Tissue | ||
| Negative | Positive | ||
| Negative |
4338.3% RT
90.0% CT 23.4% GT |
1661.7% RT
50.9% CT 37.7% GT |
|
| Positive |
26.7% RT
10.0% CT 2.6% GT |
1693.3% RT
49.1% CT 36.4% GT |
|
| Sensitivity: 50% | Specificity: 95.6% | PPV: 88.9% | NPV: 72.9% |
| SABER/MassARRAY vs. Tissue | |||
| SABER/MassARRAY | Tissue | ||
| Negative | Positive | ||
| Negative |
4338.3% RT
90.0% CT 23.4% GT |
1261.7% RT
50.9% CT 37.7% GT |
|
| Positive |
16.7% RT
10.0% CT 2.6% GT |
1493.3% RT
49.1% CT 36.4% GT |
|
| Sensitivity: 53.8% | Specificity: 97.7% | PPV: 93.3% | NPV: 78.2% |