Table 4.
Comparison of ARMS and SABER/MassARRAY methods in detecting T790M EGFR mutations from ctDNA.
| T790M ARMS vs. Tissue | |||
|---|---|---|---|
| ARMS | Tissue | ||
| Negative | Positive | ||
| Negative |
7038.3% RT
90.0% CT 23.4% GT |
461.7% RT
50.9% CT 37.7% GT |
|
| Positive |
06.7% RT
10.0% CT 2.6% GT |
293.3% RT
49.1% CT 36.4% GT |
|
| Sensitivity: 33.3% | Specificity: 100% | PPV: 100% | NPV: 94.6% |
| SABER/MassARRAY vs. Tissue | |||
| SABER/MassARRAY | Tissue | ||
| Negative | Positive | ||
| Negative |
6438.3% RT
90.0% CT 23.4% GT |
361.7% RT
50.9% CT 37.7% GT |
|
| Positive |
06.7% RT
10.0% CT 2.6% GT |
393.3% RT
49.1% CT 36.4% GT |
|
| Sensitivity: 50% | Specificity: 100% | PPV: 100% | NPV: 95.5% |
Tissue EGFR was used as the standard reference. PPV: positive predictive value; NPV: negative predictive value.