Skip to main content
. 2019 Jun 3;8(6):531. doi: 10.3390/cells8060531

Figure 5.

Figure 5

Tyrosine sorting motifs binding sites on AP complex. Crystal structures of the C-terminal domains of μ subunits of AP-1 through 4 in association with tyrosine-based sorting motifs (underlined). The C-terminal domains of μ1–4 are further subdivided into subdomain A (blue) and subdomain B (red). (A) Mouse AP-1 μ1 C-terminal domain in complex with class 1 major histocompatibility complex (MHC-1) peptide SYSQAA (PDB: 4EN2), (B) rat AP-2 μ2 C-terminal domain in complex with epidermal growth factor receptor (EGFR) peptide FYRAL (PDB: 1BW8), (C) rat AP-3 μ3A C-terminal domain in complex with TGN38 peptide SDYQRL (PDB: 4IKN), (D) human AP-4 μ4 C-terminal domain in complex with amyloid precursor protein (APP) peptide TYKFFEQ (PDB: 3L81).