Table 3.

Association between SLC2A9 and ABCG2 genes with serum uric acid levels.

		Health Workers Cohort Study		Case-Control Study -Adult		Case-Control Study -Children		Meta-Analysis (All Children and Adults)
SNP	MA	Beta (95% CI)	p Value	Beta (95% CI)	p Value	Beta (95% CI)	p Value	Beta (95% CI)	p Value	p-Value for Heterogeneity
rs11722228	T	0.33	1.1 × 10−15	0.29	1.2 × 10−8	0.42	1.6 × 10−19	0.36	1.1 × 10−17	0.0813
		(0.25, 0.41)		(0.19, 0.39)		(0.33, 0.51)		(0.27, 0.44)
rs3775948	G	−0.39	3.1 × 10−24	−0.37	2.1 × 10−16	−0.43	1.1 × 10−24	−0.40	8.2 × 10−64	0.7389
		(−0.46, −0.31)		(−0.46, −0.27)		(−0.51, −0.35)		(−0.44, −0.35)
rs1014290	G	−0.40	1.5 × 10−25	−0.31	2.3 × 10−10	−0.43	1.0 × 10−24	−0.40	2.3 × 10−64	0.6310
		(−0.48, −0.33)		(−0.41, −0.22)		(−0.51, −0.35)		(−0.44, −0.35)
rs2231142	T	0.23	5.4 × 10−8	0.23	7.2 × 10−6	0.24	2.3 × 10−7	0.23	1.0 × 10−18	0.9426
		(0.15, 0.31)		(0.13, 0.32)		(0.15, 0.33)		(0.18, 0.28)
rs3775948 conditioned for rs11722228	G	−0.31	1.2 × 10−14	−0.32	1.1 × 10−6	−0.32	2.9 × 10−13	−0.31	3.2 × 10−35	0.9857
		(−0.39, −0.23)		(−0.41, −0.22)		(−0.42, −0.24)		(−0.36, −0.26)

Models included ages (<38, 38–47, 48–57, 58–67 and >67 years), sex, body mass index (normal, overweight and obesity), glucose levels (normal, intolerance and diabetes), medications (anti-inflammatories and diuretics), menopause, family cluster and creatinine levels. SUA: Serum uric acid. The meta-analysis was performed under a random effects model.