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DNAM-1/TIGIT/PVRIG/TACTILE network and its ligands CD155 and CD112. (a) DNAM-1, TACTILE, TIGIT and PVRIG on NK and T cells interact with their ligands on tumor cells with different affinities and mediate activating and inhibitory signaling on cytotoxic cells. (b) TIGIT expressed on tumor cells may inhibit NK and T cells by interaction with CD155.
