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. 2019 Jun 23;11(6):877. doi: 10.3390/cancers11060877

Figure 3.

Figure 3

DNAM-1/TIGIT/ PVRIG/TACTILE axis in the recognition of tumor cells by NK cells. (a) The activation signals mediated by DNAM-1 (represented in yellow) recognition of its ligands, CD155 (represented in light blue) and CD112 (represented in dark blue), can be counteracted by inhibitory signaling through TIGIT and PVRIG inhibitory receptors (represented in purple and dark grey). In humans, the role of TACTILE (represented in shaded-yellow) in this balance requires a more detailed analysis. (b) Overexpression of DNAM-1 can induce lysis of some tumor cells but fails to eliminate the tumor. (c) TIGIT or PVRIG checkpoint blockade improves the responses mediated by DNAM-1 contributing to tumor elimination. (d) The combination of one or two checkpoint mAbs with co-stimulatory bispecific mAb (e.g., anti-DNAM-1 × anti-CD155) may result in better antitumor immune responses by increasing the interaction of DNAM-1 with its ligands. Cells surrounded by dotted lines represent dead cells.