Figure 3.

Somatic mutations identified in multiple regions of the primary tumour and metastases detected by whole exome sequencing (WES). The somatic mutations were classified as major or minor clonal as described in the Material and Methods section. Classification of mutations is indicated by the colours in the legend. The somatic mutations encompass 138 genes, including 11 cancer driver genes, as highlighted at the bottom of the figure. Abbreviations: Pr1, primary tumour 1; Pr2, primary tumour 2; Pr3, primary tumour 3; Pr4, primary tumour 4; VT, inferior vena cava tumour thrombus; M1, metastasis 1; M2, metastasis 2; M3, metastasis 3; M4, metastasis 4; G2, tumour grade 2; G3, tumour grade 3; G4, tumour grade 4.