Figure 2.

Heterogeneous Origins of White Adipose Tissue Depots. Adipose precursor cells of individual adipose depots originate from distinct areas of mesoderm. While Meox1/Pax3/Pax7- (from paraxial mesoderm) derived adipocytes predominate in the dorsoanterior depots, HoxB6- (lateral plate mesoderm) derived adipocytes are found largely in the ventral regions. Like Meox1/Pax3/Pax7 derived adipocytes, Mx1 and Myf5 derived adipocytes are also found in dorsoanterior depots. Adipocytes derived from the Prx1 lineage are found only subcutaneous depots, while adipocytes derived from the mesothelium and marked by Wt1 expression are only found in the visceral depots. Adipocytes derived from the Tagln lineage are found in all adipose tissue depots. Dotted lines indicate a potential connection among these lineages.