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. 2019 Apr 30;9(2):48. doi: 10.3390/diagnostics9020048

Figure 6.

Figure 6

HAMP downregulation activates the cdk1/stat3 pathway. (A) Knockdown of HAMP promotes cellular iron concentration in SMMC-7721/HepG-2 cells. (B) Cell cycle analysis of SMMC-7721 and HepG-2 cells transfected with HAMP shRNA. (C,D) HAMP downregulation activates the cdk1/stat3 pathway. (E) Downregulation of HAMP low expression of hepcidin, which promotes cellular iron concentration and then activates the cdk1/stat3 pathway to promote tumor proliferation and metastasis. # p < 0.05, * p < 0.05 and ** p < 0.01.