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. 2019 Jul 9;11:6323–6341. doi: 10.2147/CMAR.S198911

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© 2019 Cui et al.

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The JAK/STAT signaling pathway was activated after TfR1 downregulation. (A) p-Jak1 and p-Tyk2 in the JAK family were upregulated in Lenti-shTfR1 cells compared with control cells. Expression of p-Jak2 or p-Jak3 was not detected. (B) In the STAT family, p-STAT1, p-STAT3(Ser727), p-STAT5 and p-STAT6 were upregulated in Lenti-shTfR1 cells and there was a more distinct upregulation of p-STAT3(Ser727) than p-STAT3(Tyr705).