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. 2019 May 30;11(6):758. doi: 10.3390/cancers11060758

Figure 5.

Figure 5

SEMA-7A (Semaphorin7A) and Glioma Associated Stem Cells (GASC)-derived exosomes stimulate motility of Glioma Stem Cells (GSC) cell populations. (A) Representative images of scratched GSC cultures untreated (Ctrl), exposed to SEMA-7A-Fc 100 ng/mL (SEMA7A) or GASC-derived exosomes (Exo) for 8 and 24 h. (B,C) Distance covered by cells treated as described in (A) and untreated cells (Ctrl) after 8 (B) and 24 h (C) was calculated measuring the width of the gap between the two margins of scratched monolayer. Scale bar = 200 µm. Data are presented as means ± standard deviation of 4 replicates (* p < 0.01 vs. Ctrl). Statistical analysis was performed by repeated measurements one-way ANOVA followed by Dunn’s Multiple Comparison post-test (GraphPad Prism 5, San Diego, California).