Table 1.
List of 15 human proteins shared by two GASC-derived exosome preparations analysed by proteomics (Exo_S82, Exo_S104). Seven proteins were already described in Exocarta database and shown in the right column is a list of sources of exosomes in which they were observed. In bold are highlighted the six proteins not previously referenced in Exocarta.
| Accession Number | Protein | Exocarta | Origin of Exosomes |
|---|---|---|---|
| XP_005257115.2 | “collagen alpha-1(I) chain isoform X2 [Homo sapiens]” | ||
| CO6A1_HUMAN | “Collagen alpha-1(VI) chain OS = Homo sapiens OX = 9606 GN = COL6A1 PE = 1 SV = 3” | 1291 | hepatocellular carcinoma; melanoma, nasopharyngeal carcinoma, prostate cancer cells; saliva; urina |
| CO6A2_HUMAN | “Collagen alpha-2(VI) chain OS = Homo sapiens OX = 9606 GN = COL6A2 PE = 1 SV = 4” | 1292 | hepatocellular carcinoma; saliva |
| FBN1_HUMAN | “Fibrillin-1 OS = Homo sapiens OX = 9606 GN = FBN1 PE = 1 SV = 3” | 2200 | endothelial cells |
| NP_002017.1 | “fibronectin isoform 3 pre-proprotein [Homo sapiens]” | ||
| LG3BP_HUMAN | “Galectin-3-binding protein OS = Homo sapiens OX = 9606 GN = LGALS3BP PE = 1 SV = 1” | ovarian cancer | |
| G3P_HUMAN | “Glyceraldehyde-3-phosphate dehydrogenase OS = Homo sapiens OX = 9606 GN = GAPDH PE = 1 SV = 3” | 2597 | bladder, breast cancer; colorectal cancer; hepatocellular carcinoma, intestinal epithelial, melanoma, mesothelioma, neuroblastoma ovarian cancer, prostate cancer, squamous carcinoma tracheobronchial, trabecular meshwork cells; aqueous humour; hepatocytes; keratinocytes; platelets; saliva; urine. |
| LDHA_HUMAN | “L-lactate dehydrogenase A chain OS = Homo sapiens OX = 9606 GN = LDHA PE = 1 SV = 2” | 3939 | bladder, breast cancer; colorectal cancer; hepatocellular carcinoma, intestinal epithelial, melanoma, nasopharyngeal carcinoma, ovarian cancer, prostate cancer, squamous carcinoma cells; hepatocytes; platelets; thymus; urine |
| TIMP1_HUMAN | “Metalloproteinase inhibitor 1 OS = Homo sapiens OX = 9606 GN = TIMP1 PE = 1 SV = 1” | 7076 | keratinocytes; nasopharyngeal carcinoma cells; squamous carcinoma cells |
| PLTP_HUMAN | “Phospholipid transfer protein OS = Homo sapiens OX = 9606 GN = PLTP PE = 1 SV = 1” | 5360 | keratinocytes; platelets; prostate cancer cells; saliva; squamous carcinoma cells |
| PAI1_HUMAN | “Plasminogen activator inhibitor 1 OS = Homo sapiens OX = 9606 GN = SERPINE1 PE = 1 SV = 1” | ||
| AAC34741.1 | “semaphorin L partial [Homo sapiens]” | ||
| TRFE_HUMAN | “Serotransferrin OS = Homo sapiens OX = 9606 GN = TF PE = 1 SV = 3” | ||
| QSOX1_HUMAN | “Sulfhydryl oxidase 1 OS = Homo sapiens OX = 9606 GN = QSOX1 PE = 1 SV = 3” | ||
| SJM31191.1 | “Sulfotransferase [Homo sapiens]” |