Table 1.

Studies of prescription dose comparison in radiosurgery of trigeminal neuralgia. * Linear accelerator radiosurgery, REZ = dorsal root entry zone, RG = retrogasserian.

Study	Max Dose to Nerve	Dose Related Pain Freedom	Facial Numbness Dose Related	Radiosurgery Target
Kondziolka et al. [5]	≤65 Gy ≥70 Gy	Yes ≥ 70 Gy p = 0.02	No relationship	REZ
Pollock et al. [8]	70 Gy 90 Gy	No difference	Yes. Numbness and dysesthesia	REZ
Alpert et al. [14]	≤80 Gy 85 Gy ≥90 Gy	Yes, with escalating doses p < 0.001	No relationship	REZ ±second shot 3–4 mm more distal
Sheehan et al. [9]	50–90 Gy	No difference	No relationship	REZ
Tawk et al. [10]	70, 80, or 90 Gy	No difference	Trend to dose relationship	REZ
Morbidini-Gaffney et al. [18]	<80 Gy 85 Gy >85 Gy	Yes < 85 Gy p < 0.001		REZ ±second shot 2–4 mm more distal
Régis et al. [11]	70–90 Gy	No difference	No relationship	7.5 mm anterior to pons
Fountas et al. [7]	75–85 Gy	No difference		REZ
Longhi et al. [15]	75–95 Gy >80 Gy	Yes > 80 Gy p = 0.008	>90 Gy increased numbness	REZ
Chen et al. * [6]	85 or 90 Gy	No difference		Cisternal nerve segment
Matsuda et al. [16]	80 or 90 Gy	No difference	Trend to more numbness in 90 Gy RG target	80 Gy REZ 90 Gy RG target
Kim et al. [13]	75 or 85 Gy	No difference	No relationship	REZ
Smith et al. * [17]	70 or 90 Gy	Yes, at one year	Trend to dose relationship	REZ
Zhang et al. [12]	75 or 90 Gy	No difference	No dose relationship	Cisternal portion of nerve with one or two isocenters
Kotecha et al. [19]	≤82, 83–86, or ≥90 Gy	Improved > 82 Gy	No dose relationship prescription doses ≥ 83 Gy	REZ
Massager et al. [20]	70–85 Gy, 90 Gy, or 90 Gy with shielding	No, trend to better pain freedom in higher dose	Yes. Numbness related with higher dose	Anterior cisternal nerve segment
Villavicencio et al. * [21]	Range of 50–80 Gy, median 75 Gy	Yes, related with longer nerve segment treated	Yes	REZ