Figure 1.

Main signaling pathways downstream GαQ or Gα11 and their inhibitors. Inhibitors of specific signaling molecules are depicted in red line boxes. GPCR: G protein-coupled receptor; CYSLT2R: Cysteinyl leukotriene receptor 2; PKCδ/ε: Protein kinase C delta/epsilon; RASGRP3: RAS guanyl releasing protein 3; PLCβ: Phospholipase C beta; DAG: Diacylglycerol; PIP2: Phosphatidylinositol biphosphate; IP3: Inositol 1,4,5-trisphosphate; ARF6: ADP ribosylation factor 6; TRIO: Trio rho guanine nucleotide exchange factor; RHO: Ras homologue family member; ROCK: Rho-associated, coiled-coil-containing protein kinase; Rac: Rac family small GTPase 1; FAK: Focal adhesion kinase; MOB1: MOB kinase activator 1; LATS: Large tumor suppressor kinase; Yap: Yes associated protein 1; PI3K: Phosphatidylinositol-4,5-bisphosphate 3-kinase. This figure was adapted from Yang et al. [1].