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. 2019 Jun 17;8(6):600. doi: 10.3390/cells8060600

Figure 1.

Figure 1

Domain architecture of human TEADs. The N-terminal DNA binding domain (DNA-BD) and C-terminal YAP/TAZ binding domain (YAP/TAZ-BD) of TEAD1-4 harbor high similarity across four different paralogs. The percent (%) represents the identity for each domain of TEADs compared to that of TEAD1 [50]. TEAD post-translation modifications include palmitoylation and PKA-, PKC-mediated phosphorylation that occur in the YAP/TAZ-BD and DNA-BD, respectively. Palmitoylation is required for proper TEAD functions. TEAD cytoplasmic translocation occurs through protein-protein interaction with p38 MAPK that binds the p38-binding motif within the DNA-BD of all TEADs.